Centromeres and Kinetochores

This book presents the latest advances concerning the regulation of chromosome segregation during cell division by means of centromeres and kinetochores. The authors cover both state-of-the-art techniques and a range of species and model systems, shedding new light on the molecular mechanisms controlling the transmission of genetic material between cell divisions and from parent to offspring.

The chapters cover five major areas related to the current study of centromeres and kinetochores: 1) their genetic and epigenetic features, 2) key breakthroughs at the molecular, proteomic, imaging and biochemical level, 3) the constitutive centromere proteins, 4) the role of centromere proteins in the physical process of chromosome segregation and its careful orchestration through elaborate regulation, and 5) intersections with reproductive biology, human health and disease, as well as chromosome evolution. The book offers an informative and provocative guide for newcomers as well as those already acquainted with the field.

Aceasta carte prezinta cele mai recente progrese in ceea ce priveste reglarea segregarii cromozomiale in timpul diviziunii celulare prin intermediul centromerilor si kinetocorilor. Autorii acopera atat tehnici de ultima generatie, cat si o serie de specii si sisteme de modele, aruncand o noua lumina asupra mecanismelor moleculare care controleaza transmiterea materialului genetic intre diviziunile celulare si de la parinte la descendenti. Capitolele acopera cinci domenii majore legate de la studiul actual al centromerilor si kinetocorilor: 1) caracteristicile lor genetice si epigenetice, 2) descoperiri cheie la nivel molecular, proteomic, imagistic si biochimic, 3) proteinele constitutive ale centromerului, 4) rolul proteinelor centromere in procesul fizic a segregarii cromozomiale si orchestrarea atenta a acesteia printr-o reglementare elaborata si 5) intersectii cu biologia reproducerii, sanatatea si bolile umane, precum si evolutia cromozomilor.