Methods for Reversing Protein Modification

Protein posttranslational modification with peptide tags ubiquitin or small ubiquitin-like modifier (SUMO) orchestrate multiple cellular events to ensure normal physiology. These simple enzymatic activities maintain homeostasis of protein modification and normal cell function. This book addresses major proteases - ubiquitin and/or SUMO proteases - involved in posttranslational modification of proteins. Themes reviewed include the difficulty of assigning substrate specificity to the individual de-ubiquitylases (DUBs), selectivity for processing ubiquitin poly-chains, and defining substrate profiles for the different SUMO proteases.

Modificarea posttranslationala a proteinelor cu etichete peptidice ubiquitin sau mic modificator asemanator ubiquitinei (SUMO) orchestreaza multiple evenimente celulare pentru a asigura fiziologia normala. Aceste activitati enzimatice simple mentin homeostazia modificarii proteinelor si a functiei celulare normale.