Structural Basis of Arrestin Functions

Recent studies showed that arrestins are important signal transducers in their own right, organizing multi-protein complexes and scaffolding numerous signaling cascades that regulate cell proliferation, differentiation, and apoptotic death. Here arrestin functions are described primarily from the structural prospective.

Studii recente au aratat ca arrestinele sunt traductoare de semnal importante in sine, organizand complexe multi-proteice si scheland numeroase cascade de semnalizare care regleaza proliferarea celulara, diferentierea si moartea apoptotica. Aici functiile de arestare sunt descrise in primul rand din perspectiva structurala.