Thiamine Deficiency Disease, Dysautonomia, and High Calorie Malnutrition

Thiamine Deficiency Disease, Dysautonomia, and High Calorie Malnutrition explores thiamine and how its deficiency affects the functions of the brainstem and autonomic nervous system by way of metabolic changes at the level of the mitochondria. Thiamine deficiency derails mitochondrial oxidative metabolism and gives rise to the classic disease of beriberi that, in its early stages, can be considered the prototype for a set of disorders that we now recognize as dysautonomia. This book represents the life's work of the senior author, Dr. Derrick Lonsdale, and a recent collaboration with his co-author Dr. Chandler Marrs.

Boala cu deficit de tiamina, disautonomia si malnutritia bogata in calorii exploreaza tiamina si modul in care deficienta acesteia afecteaza functiile trunchiului cerebral si ale sistemului nervos autonom prin schimbari metabolice la nivelul mitocondriilor. Deficitul de tiamina deraiaza metabolismul oxidativ mitocondrial si da nastere bolii clasice a beriberilor care, in stadiile incipiente, poate fi considerat prototipul unui set de tulburari pe care le recunoastem acum drept disautonomie.