Thyroid Hormone Nuclear Receptor

This volume aims to detail the advances in the field of Thyroid hormones (THs), namely T3 and T4, and their nuclear receptor TRs from a conceptual and methodological point of view. Chapters guide readers through a general introduction, TR's engineered mice, human genetics of TRs, control of the hypothalamus-pituitary-thyroid (HPT) axis, the relevance of the local THs production and metabolism and pathological consequences of TH/TR alterations. Non-mammalian models are also presented and discussed. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.



Authoritative and practical, Thyroid Hormone Nuclear Receptor: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Acest volum isi propune sa detalieze progresele in domeniul hormonilor tiroidieni (THs), si anume T3 si T4, si TR-urile receptorilor lor nucleari din punct de vedere conceptual si metodologic. Capitolele ghideaza cititorii printr-o introducere generala, soarecii ingineri ai TR, genetica umana a TR, controlul axei hipotalamus-hipofiza-tiroida (HPT), relevanta productiei si metabolismului local de THs si consecintele patologice ale modificarilor TH / TR.