Basic Principles of Drug Discovery and Development

Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, providing comprehensive explanations of enabling technologies such as high throughput screening, structure based drug design, molecular modeling, pharmaceutical profiling, and translational medicine, all areas that have become critical steps in the successful development of marketable therapeutics.

The text introduces the fundamental principles of drug discovery and development, also discussing important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles in pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. It is designed to enable new scientists to rapidly understand the key fundamentals of drug discovery, including pharmacokinetics, toxicology, and intellectual property.

Principiile de baza ale descoperirii si dezvoltarii medicamentelor prezinta procesul multifacetic de identificare a unui medicament nou in epoca moderna, oferind explicatii cuprinzatoare ale tehnologiilor abilitatoare, cum ar fi screeningul cu randament ridicat, proiectarea medicamentelor bazate pe structuri, modelarea moleculara, profilarea farmaceutica si medicina translationala, toate domeniile care au devenit pasi critici in dezvoltarea cu succes a terapeuticii comercializabile. Textul introduce principiile fundamentale ale descoperirii si dezvoltarii medicamentelor, discutand, de asemenea, tinte importante de medicamente pe clase, metode de screening in vitro, strategii de chimie medicamentoasa in proiectarea medicamentelor, principii in farmacocinetica si farmacodinamica , modele animale ale starilor de boala, elementele de baza ale studiilor clinice si aspecte comerciale selectate ale procesului de descoperire a medicamentelor.