Permeability of Biological Membranes

This book deals with biological membranes, focuses on permeabilization and pays particular attention to reversible permeabilization to maintain the viability and physiological conditions of the cells.

Selective permeability of biological membranes also known as semipermeability, partial permeability or differential permeability allows molecules to diffuse, pass by passive and active or by other types of transport processes mediated by proteins.

The first chapter of the book deals with the composition of biological membranes, characterizes cellular membranes of prokaryotic, eukaryotic cells, membranes of cellular organelles and the function of biological membranes. The second chapter provides an overview of bilayer permeability, selectivity of permeabilization and cellular transport processes. Chapter 3 overviews different cell manipulations that aim to make cells permeable while maintaining not only the structural but also the functional integrity of cells. The last chapter deals with applications, particularly with reversible permeabilization to study macromolecular (DNA, RNA, poly-ADP ribose) biosynthetic processes, replication, gene expression, visualization of replicons, intermediates of chromosome condensation, genotoxic chromatin changes, upon treatment with heavy metals and different types of irradiation.



The interdisciplinary aspects of the book contribute to the understanding of the structure of nucleic acids, replicative intermediates, Okazaki fragments, RNA primer mechanism, subphases of replication and repair synthesis, replicons, gene expression, chromosome condensation generated a wealth of information that will attract a wide readership. The natural audience engaged in DNA research, including genetics, cell and molecular biology, chemistry, biochemistry, medicine, pharmacy will find essential material in the book.

Aceasta carte trateaza membranele biologice, se concentreaza pe permeabilizare si acorda o atentie deosebita permeabilizarii reversibile pentru a mentine viabilitatea si conditiile fiziologice ale celulelor. Permeabilitatea selectiva a membranelor biologice cunoscute si sub denumirea de semipermeabilitate, permeabilitate partiala sau permeabilitate diferentiala permite moleculelor sa difuzeze, sa treaca pasiv si activ sau prin alte tipuri de procese de transport mediate de proteine. Primul capitol al cartii se refera la compozitia membranelor biologice, caracterizeaza membranele celulare ale celulelor procariote, eucariote, membranele organelor celulare si functia membranelor biologice.